Open-label study
Open-label study
Participants and health professionals know which treatment is being given; also called nonblinded.
How to read it
Check the comparator, outcome measurement and whether outcome assessors are blinded. An open-label study can still be randomized and controlled.
A common pitfall
Knowledge of treatment can influence reporting, care or assessment. Evaluate outcome objectivity and bias controls rather than dismissing the study automatically.
Read it in context
Genmab’s Rina-S: Revisiting a $1.8 Billion Acquisition →Relyvrio: How Much Certainty Is Enough When Patients Cannot Wait? →Why keep a targeted drug after resistance develops? →When Options Are Few, How Should We Judge Progress in Osteosarcoma? →J&J’s Rybrevant Beyond Lung Cancer: What the New Approval Changes →Related concepts to distinguish
Arms describe groups; randomization describes assignment; masking describes who knows the treatment; endpoints describe what is measured.